Fluctuations in hormones like estrogen and progesterone can lead to increased melanin production in the body. Postmenopausal women may develop Melasma due to progesterone treatment. Genetic ...

According to the Cleveland Clinic, melasma is a harmless skin condition that causes brown or blue-gray patches or "freckle-like spots" on the body. The markings most commonly appear on one’s ...

Melasma, also called as chloasma, is a skin hyperpigmentation problem characterized by brown spots and patches on the face and other body parts exposed to the sun.

[19] This may be the other mechanism of action of Silymarin in the treatment of melasma. Silymarin inhibited l-DOPA oxidation activity of tyrosinase, the rate-limiting melanogenic enzyme ...