Lysosomes are dynamic organelles in eukaryotic ... of genes involved in autophagosome biogenesis and autophagy-lysosomal fusion. “Natural products are an important source of small-molecule ...

The hetero-octameric complex BORC recruits the small G protein ARL8 to mediate the transport and localization of lysosomes. BORC-ARL8 is an essential regulatory factor in the fusion of lysosomes ...

Q1 2023 Earnings Call Transcript April 15, 2025 Spruce Biosciences, Inc. misses on earnings expectations. Reported EPS is $-0 ...

resulting in partial lysosomal membrane permeabilization and blocking of autophagosome-lysosome fusion. These alterations lead to increased accumulation of autophagic structures, blocking autophagic ...

These findings suggest that people with gum disease, especially those infected with P. gingivalis producing gingipain, may be at greater risk of serious complications if they suffer a heart attack.

which is an inhibitor of autophagy by raising lysosomal pH and therefore preventing autophagosome–lysosome fusion.40 Similarly, many pharmaceuticals approved in the European Union and USA, and in ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

These rare neurodegenerative diseases are characterized by the dysfunction of lysosomes, cellular organelles that break down various substances ready for disposal, including proteins, nucleic ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.