The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...

The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, ...

To decipher the role of ECM in modulating cellular phenotype, disease-relevant cell types are then re-seeded ... Pharmaceuticals in advanced fibrotic liver diseases and fibrostenotic inflammatory ...

HHMI researchers solve a longstanding mystery about the origin of new cells in the liver. Howard Hughes Medical Institute (HHMI) scientists have identified stem cells in the liver that give rise to ...

Fibrosis can occur in any tissue or organ in the body, including the lungs, liver, kidney and heart ... and fibrosis. But the cells activated to make new ECM were neither really dormant, nor ...

Ammonia buildup damages liver cells by harming mitochondria, leading to cell death and liver injury. An existing drug, YAQ-005, can prevent this damage by halting mitochondrial harm, allowing ...

Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators in liver fibrosis—have a commanding role in ...

Korean researchers develop new drug candidate 19c for liver fibrosis treatment Researchers unveil promising new agent 19c in ...

As noted above, stellate cell activation is the central ... protease activity play an important role in ECM remodeling accompanying fibrosing liver injury (see section on Extracellular Matrix ...

High levels of ammonia kill liver cells by damaging the mitochondria that power the cells. But this can be prevented using an existing drug due to start clinical trials, finds a new study in mice.