The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...

The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, ...

HHMI researchers solve a longstanding mystery about the origin of new cells in the liver. Howard Hughes Medical Institute (HHMI) scientists have identified stem cells in the liver that give rise to ...

Fibrosis can occur in any tissue or organ in the body, including the lungs, liver, kidney and heart ... and fibrosis. But the cells activated to make new ECM were neither really dormant, nor ...

New research suggests restoring stellate cells to their healthy and protective state could simultaneously reduce liver scarring and improve liver function.

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers from the German Cancer Research ...

Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators in liver fibrosis—have a commanding role in ...

Korean researchers develop new drug candidate 19c for liver fibrosis treatment Researchers unveil promising new agent 19c in ...

As noted above, stellate cell activation is the central ... protease activity play an important role in ECM remodeling accompanying fibrosing liver injury (see section on Extracellular Matrix ...