Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

Pathological cardiac hypertrophy is the abnormal enlargement of the heart muscle in response to chronic stressors such as hypertension, myocardial infarction, or valvular disease. This maladaptive ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. As a common and severe cerebrovascular disease ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

2005; Gack et al., 2007; Chen et al., 2016). In addition, K63 ubiquitination in the RIG-I CTD mediated by the Riplet E3 ligase has also been shown to be required for RIG-I activation (Oshiumi et al., ...

In this study, we demonstrated that Cullin3-TNFAIP1 complex targeted RhoB for ubiquitination and subsequent proteasome-dependent degradation in hepatocellular carcinoma (HCC) cells. Moreover, TNFAIP1 ...

Although post-translational modification of cellular proteins with ubiquitin is a key molecular mechanism governing protein degradation and function, mGlu7 ubiquitination and its functional ...