The off-label use of JAK inhibitors to treat JDM is common in pediatric rheumatology, with barriers to use including limited clinical trial data and insurance approval.

The mystery of a pyramid structure that was found under the sea off the coast of the Azores Islands in 2013 is still puzzling experts who are not certain whether it is human-made. Diocleciano Silva ...

State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China ...

Janus kinase (JAK) inhibitors are an important treatment option for people with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis.

[Courtesy of Callegari et al., Science, 2025.] In the human structure, researchers spotted signs that the kinase domain had shifted toward an activated state, indicating that autophosphorylation had ...

What Is Mevalonate Kinase Deficiency? Mevalonate kinase deficiency (MKD) is a disease that runs in families. A problem with your immune system causes attacks of fever and symptoms like swollen ...

Four qualities that elevate this paper from good to great in style are: its structure, captivity, soulfulness, and precision. Structured Outline, Paragraphs, and Sentences Structurally ...

Interdisciplinary Research Centre for Membranes and Water Security, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia Mechanical Engineering Department, King Fahd University ...

python3 -m pip install git+https://github.com/stfc/janus-core.git By default, no machine learnt interatomic potentials (MLIPs) will be installed with janus-core ...