The San Francisco 49ers may once again look to revamp their defensive line after an underwhelming performance last season. Despite efforts to bolster the unit, the results fell short of expectations.

Deebo Samuel is expressing appreciation for his now former fans. The San Francisco 49ers dealt Samuel to the Washington Commanders on Saturday, ending his six-year tenure with the franchise.

Deebo Samuel's trade request has been granted. The San Francisco 49ers wide receiver is heading to the Washington Commanders for a fifth-round pick in the 2025 NFL Draft, according to NFL Network ...

Nov 12, 2018; Santa Clara, CA, USA; A general overall view of the San Francisco 49ers logo at midfield at Levi’s Stadium prior to the game against the New York Giants. Mandatory Credit ...

San Francisco 49ers general manager John Lynch doesn't know when a contract extension for quarterback Brock Purdy will be done, but he said Wednesday that discussions toward that outcome have ...

You can find him at X @james_brizuela. The San Francisco 49ers have a lot of tasks to get done this offseason. One is giving Brock Purdy his well-deserved and long-awaited contract extension ...

European Patent Office grants new CRISPR/Cas9 patent (EP 4 289 948) to CVC, with broad claims covering guide RNAs and their combination with Cas9. Patent strengthens CVC's leading position in ...

When the 49ers announced their full coaching staff for 2025, one name was conspicuously absent. Brian Griese is out after three years as the team’s quarterbacks coach, working for coach Kyle Shanahan.