This pathway senses inflammation and actively suppresses dopamine—a key driver of motivation—resulting in apathy and loss of ...

Recent studies have shown that CRP exacerbates kidney inflammation and fibrosis through the TGF-β/Smad3 signaling pathway, worsening DKD. The activation of the NLRP3 inflammasome is a key factor ...

Scientists have identified tricellulin loss as the root cause of dry mouth in Sjögren's syndrome, and successfully reversed ...

Targeting JAKs is thought to help suppress overactive cytokine pathways, reducing inflammation — and, as a result, has been used to treat several systemic immune-related inflammatory diseases ...

Researchers discover that inflammation and aging contribute to non-viral liver cancer development: Green tea's role in reversing some of the pathway dysregulation that may contribute to the cancer ...

It found that higher levels of these inflammatory markers were linked to increased production of neurotoxic chemicals in the kynurenine pathway. Notably, this association was found in adolescents ...

Alzheimer’s disease, the most common cause of dementia, is currently incurable. The current drugs available have very limited efficacy and only in mild stages of the disease. A team from the ...

A modern Western diet, high in processed foods and low in whole plant-based foods, can contribute to chronic inflammation but ...

Researchers identified a direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer. In a mouse study, they describe a brain pathway that starts ...

This pathway senses inflammation and actively suppresses dopamine—a key driver of motivation—resulting in apathy and loss of drive. Blocking the pathway restored motivation, even though the ...

In a mouse study, they describe a brain pathway that starts with neurons (labeled in green, above) that sense inflammation signals, and the researchers were able to treat the loss of motivation by ...

However, new research from Washington University School of Medicine in St. Louis has identified a specific brain pathway that directly links cancer-related inflammation to a drop in motivation.