Given that human basophils express CLEC12A, a protein that is also highly expressed on the surface of pre-basophils in mice, it seems likely that there is a human counterpart of mouse pre-basophils.

Human mast cells and basophils that express the high-affinity immunoglobulin E (IgE) receptor, Fcɛ receptor 1 (FcɛRI), have key roles in allergic diseases. FcɛRI cross-linking stimulates the ...

In human physiology, basophils play an important role in the programming of Th2 responses, and support B cell differentiation and antibody production through production of various cytokines and ...

Basophils account for just one in a hundred white blood cells but immunologists have speculated for some time that they can enhance our immune defense against pathogens. Using genetically modified ...

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nature Immunology , 2019; 20 (2): 129 DOI: 10.1038/s41590-018-0288-7 Cite This Page : ...

Basophils also play a role in your acquired immunity, especially against various tick infections and helminths. Helminths are parasitic worms and include parasites such as tapeworms and roundworms.

There are a group of cells dedicated to defending our bodies from all comers, these are the immune cells. Like an army, there are members that perform different tasks and that specialize in different ...

Basophil activation might serve as predictive biomarker of treatment success, ... including AI, as part of the process. Human editors reviewed this content before publication. 0. Credit. Lead ...

Basophils from each strain were stimulated with antigen combined with IgE, IL-33, or lipopolysaccharide (LPS). We measured ...

Basophils also play a role in a wide variety of allergic and autoimmune responses. These include allergic reactions of the skin, respiratory tract and gastrointestinal tract. When the body contacts an ...