Award-winning research presented by Hangjie Fu at EHA shows that ellagic acid can protect against iron overload-induced liver ...

Positive updates across all programs, including longer term efficacy and safety data from the HELIOS open-label extension trial of bitopertin in erythropoietic protoporphyria (EPP), additional ...

As multiple companies vie to expand on Alnylam’s success in commercializing RNAi therapeutics, the pioneering company has set ...

Disc Medicine, Inc. (NASDAQ:IRON), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel treatments for patients suffering from serious ...

And further experiments showed that removing any of the other enzymes in the heme biosynthesis pathway did not affect microRNA levels. "This told us that ALAS1 has another job outside of helping ...

“We propose that the need to assimilate and detoxify ammonium from heme biosynthesis and other metabolic processes led to the selective activation of glutamine synthesis as a specialized ...

From the Department of Medicine and Aging (L.D.F., M.D., A.D.F., T.S., P.P.), “G. d’Annunzio” University, Chieti, Italy; CeSI (L.D.F., M.D., A.D.F., T.S., A ...

Erythropoietic protoporphyria and X-linked protoporphyria are inborn errors of heme biosynthesis that cause elevated circulating levels of metal-free protoporphyrin and phototoxicity. Both ...

While many disorders of heme synthesis are caused by mutations in genes directly associated with heme biosynthesis, iron-sulfur cluster formation or iron transport, a smaller subset of tissue-specific ...

A new androgen biosynthesis inhibitor drug improved progression ... Teuton Professor of Medicine in the Division of Hematology and Oncology and a co-author of the study. We have entered a new ...

Hence, two alternative approaches for chromophore biosynthesis and insertion into phytochrome evolved in plants and fungi. Heme oxygenase activity converts heme into a linear tetrapyrrole for ...