In this important study, the authors have performed a zebrafish drug screen to identify suppressors of atherogenic lipoproteins. They utilize a well-established LipoGlo assay to find molecules that ...

We next aimed to determine whether HNF4⍺ is genetically required for normal B-lp levels throughout larval development. We obtained a loss of function allele of HNF4⍺, rdu14 [64], and crossed the ...

These bioactives have the ability to activate HNF4⍺, a transcription factor shown to play a key role in gut barrier function and integrity.

imageimageBy combining the analysis of active enhancer profiles and genomic structural variation, a lineage-specific super enhancer for MYB in gastrointestinal adenocarcinoma was discovered and ...

For example, the study identified HNF4 and GATA motifs as crucial for activity in hepatocytes and lymphocytes, respectively.

Fibrillarin homologs regulate translation in different cell lineages during planarian homeostasis and regeneration.

Researchers are testing the use of mRNA to get damaged livers to repair themselves, in a move that could one day lessen the need for organ transplants.

ACAT2, one member of ACAT family catalyzing formation of cholesterol esters, is important for cholesterol ester synthesis and VLDL/ApoB secretion. To explore how ACAT2 quantity is regulated, we ...

Abstract. Despite recent advances in the treatment of pancreatic adenocarcinoma (PDAC), the median survival remains <12 months. Patients typically present with late-stage disease and have limited ...

Dysregulated expression of HNF4 results in a wide range of disease manifestations, including the development of a chronic inflammatory state in the intestine. In this review, we focus on the multiple ...