Two decades ago, a link between apoptosis and cancer was recognized, following the discovery that the protein BCL-2 specifically blocked apoptotic death of B cells in follicular lymphoma.

That analysis found that male sex, poor performance status, elevated beta-2 microglobulin, and a high Follicular Lymphoma International Prognostic Index (FLIPI) score were associated with an ...

As a lymphoma survivor, I struggle with the positivity trap — sometimes, I just want my fears validated instead of being ...

Opens in a new tab or window Follicular lymphoma -- typically a slow-growing ... versus the rituximab-chemotherapy group (69.5 vs 31.2 months; HR 0.58, 95% CI 0.44-0.74, P<0.0001).

Follicular lymphoma is a diverse disease, both biologically and clinically. Patients may present with indolent, asymptomatic disease or more aggressive, symptomatic disease with high tumor burden.

bcl-2, CD10, cyclinD1, CD15, CD30, ALK-1, CD138 may be used in various blood cancers or hematologic malignancies. Consider follicular lymphoma (FL) in a bit more depth as an example of other ...

Additionally, it is approved for adults with relapsed or refractory follicular lymphoma who have undergone at least two prior systemic therapies and for relapsed or refractory mantle cell lymphoma ...

Follicular lymphoma (FL) is the second most common form of NHL ... inhibitor and a B-cell lymphoma 2 (BCL-2) inhibitor. This indication is approved under accelerated approval based on response rate ...

The new use is the third for Kymriah (tisagenlecleucel) in the EU and offers patients with grade 1, 2 and 3A follicular lymphoma that has returned after two or more prior treatments a new ...