Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, London, UK Correspondence to: Dr H E Montgomery British Heart Foundation Laboratories, Royal Free & University College ...

IL-1β (interleukin-1β) is a proinflammatory cytokine that causes cardiac hypertrophy and heart failure. Here, we show that neural signals activate the NLRP3 (nucleotide-binding domain, ...

Objectives: In this study, we investigated whether pioglitazone affects cardiomyocyte apoptosis and hypertrophy by regulating the VEGFR-2 signaling pathway. Methods: Cardiomyocytes were enzymatically ...

Heart failure is one of the leading causes of death worldwide and has been singled out as an emerging epidemic. 1, 2 With a 5‐year survival rate of 50%, heart failure poses a tremendous burden on our ...