In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis.The core event in this pathway ...

Workplace stress, on the rise for decades, has been treated by many organizations as a personal issue instead of a business-critical risk that merits executive oversight. This is likely due in ...

ER stress results in activation of the unfolded protein response and has been implicated in the development of fibrotic diseases. In this study, we show that inhibition of the ER stress‐induced IRE 1α ...

Here, we report a spatially coordinated mechanism at endoplasmic reticulum–plasma membrane (ER–PM) contact sites, where Synaptotagmin 1 (SYT1) transports ... Arabidopsis AtPLC2 is a primary ...

The intestinal epithelium is susceptible to heat stress (HS), which leads to gut leakage and inflammation. However, the mechanisms underlying HS-induced intestine dysfunction have yet to be elucidated ...

Introduction. Pathological cardiac hypertrophy is typically characterized by increased cardiac myocyte cell size, interstitial fibrosis, myocyte apoptosis, and contractile dysfunction (Heineke and ...

Paraoxonase 2 is found in intracellular structures, such as the membranes of the ER or mitochondria, where it reduces superoxide formation and ER stress signaling. 115,116 Interestingly, paraoxonase 2 ...

1. Stress Hormones Put Your Body in Fight-or-Flight Response . The body's fight-or-flight response can affect the entire body, including your blood pressure. This stress response is the body's ...

Although isothiazolinones (ITs) are widely used as antimicrobials in various products, the understanding of their hazards remains incomplete. This study aimed to evaluate the adverse effects of ITs at ...

Adrian L Lopresti. The Effects of Psychological and Environmental Stress on Micronutrient Concentrations in the Body: A Review of the Evidence. Advances in Nutrition. January 2020. Coping with Stress.