The evolution of low-temperature adapted enzymes Scientists uncover how enzymes evolved to function at low temperatures by reconstructing prehistoric proteins from extinct bacteria Date: March 25 ...

Digestive enzymes are found in the digestive system, including the mouth, stomach, and small intestine. They help you break down food and absorb nutrients. Sometimes, the body cannot make enough ...

As a deubiquitinating enzyme, mysm1 regulates trim 21 stability and mediates doxorubicin (DOX) - induced ferroptosis in cardiomyocytes, suggesting that cardiomyocyte specific knockdown of mysm1 may be ...

In this study, we verified that the expression of the proteasome protein PSMD11 and the deubiquitinating enzyme PSMD14 in pancreatic cancer was increased in PDAC tissues. An analysis of the ...

Get Instant Summarized Text (Gist) Enzymes capable of degrading plastic have been identified in landfills worldwide, suggesting a potential method for plastic waste recycling. Using metagenomics ...

The findings could also provide starting points for new drugs against pathogens with similar respiratory enzymes. More information: Anuj Kumar et al, Molecular principles of redox-coupled sodium ...

Furthermore, TBBPA enhances hepatic cholesterol synthesis by elevating protein levels of HMGCR, which is the rate-limiting enzyme in cholesterol biosynthesis. This effect is mediated through increased ...

Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 ...

A surprising paradox emerging from recent studies is that ubiquitin ligases (E3s) and deubiquitinases (DUBs), enzymes with opposing activities, can both promote ERAD. Here we demonstrate that the ERAD ...