Phosphodiester bonds are crucial components of nucleic acids, linking nucleotides together in DNA and RNA. Understanding the mechanisms by which these bonds are cleaved is essential for various ...

The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response ... seal the two ends ...