Proteins will be recognised on either side (ER lumen or cytosolic) or within the ER membrane. After recognition, misfolded proteins in the lumen and membrane are retrotranslocated to the cytosolic ...

Since it first landed in 2019, China's Chang'e-4 — the first spacecraft to ever land on the far side of the moon — has been taking stunning panoramas of impact craters and sampling minerals ...

Mitochondrial PQC occurs at the cytosolic side of the OMM to survey the import of nuclear-encoded proteins, in the intermembrane space and in the matrix to control their state and turnover. In this ...

The cytosolic side of this membrane-spanning protein domain is cysteine-rich and capable of undergoing protein palmitoylation, the reversible addition of palmitic acid. Study: Inhibition of SARS ...

Side (left) and top (right) views of the A ... Representative densities of the A, N, and P cytosolic domains and TM helices in the present cryo‐EM map of SERCA2b in the E1∙2Ca 2+ state. Segments are ...

The emerging nascent membrane protein (red) disrupts contacts between TM 2 and TM 7 on the cytosolic side of the membrane further, while TM 7 moves closer toward TM 3 on the periplasmic side. This ...

However, a substrate-binding site on the cytosolic side has not been found, and the transport mechanisms of P4 ATPases with other substrates are unknown. Here, we report structures of the S.

Data information: All structures are shown from a view focusing on the lateral gate (left) and from the top (cytosolic side; right). Structure alignments are based on TMs 7–9 of Sec61α. Black arrows ...

An enzyme accessibility assay confirmed that the protein orientation is preserved and results in the extracellular domain facing toward the bulk phase and the cytosolic side facing the support.

Images were acquired using a Morada 11 Megapixel side‐mounted transmission electron microscope CCD camera (Olympus Soft Imaging Solutions, Münster, Germany). Digitally, using iTEM software, we have ...

How did USP19 mediate the secretion of MAPS substrates? Because USP19 is anchored to the cytosolic side of the ER membrane via a transmembrane domain at its C-terminus, the researchers investigated ...