Autophagic cell death occurs in the absence of chromatin condensation but is accompanied by massive autophagic vacuolization of the cytoplasm. Although the term autophagic cell death suggests that ...

Cholestasis in general is classified as either extrahepatic, where there is a mechanical obstruction to the main bile ducts, or intrahepatic, where such an obstructive lesion cannot be ...

"Part of the reason why the underlying mechanisms are still poorly understood is that we lack model systems that reliably recapitulate both the nuclear depletion of TDP-43 and its cytoplasmic ...

Pregnancy-associated changes usually are noted, including intracytoplasmic or supranuclear vacuolation and secretions in gland lumens. Fibroadenomas and mammary hamartomas (Fig. 1) can enlarge ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lipid transfer proteins mediate the ...

Pursuant to section 74 of the Canadian Environmental Protection Act, 1999 (CEPA), the Ministers of the Environment and Climate Change and of Health have conducted a screening assessment on Phenol, ...

Background: Non-alcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease and its incidence is increasing. Its disease progression is closely related to non-alcoholic ...

Background Since the publication of the EULAR recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in 2016, several randomised clinical trials ...

1 The First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China 2 Six Sections of Geriatrics, Affiliated Hospital of Shandong University of ...

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. Antibodies targeting folate receptor 1 (FOLR1) induce autophagic cell death in ...

Full-length Notch-1 (300 kDa) and extracellular fragment (200 kDa) were also observed in addition to cytoplasmic domain (120 kDa) as per the manufacturer's instructions. For each 25 cm 2 flask of ...