Zhou SF, Xue CC, Yu XQ, Li C, Wang G. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther ...

In comparison to imidazole (IMZ) and 1,2,4-triazole (1,2,4-TRZ), the isosteric 1,2,3-triazole (1,2,3-TRZ) is unrepresented among cytochrome P450 (CYP) inhibitors. This is surprising because 1,2,3-TRZs ...

Cytochrome P450 (CYP450) enzymes are membrane-bound blood proteins that are vital to drug detoxification, cell metabolism ... Aitken, A. E., and Morgan, E. T. (2007). Gene-specific effects of ...

Total cytochrome P450 (CYP) Analysis of CYP was based on the methods described before (Omura and Sato, 1964, Johannesen and Depierre, 1978) using differential visible spectroscopy with some ...

"Notably, unlike clopidogrel, which is metabolically activated via cytochrome P450 2C19 (CYP2C19), prasugrel is primarily activated through cytochrome P450 3A4 and 2B6," Kang and colleagues wrote.

Inherent with the mechanism of pharmacology for this compound was the inhibition of cytochrome P450 3A4 (P450 3A4), observed from early ADME screening. Further investigation showed that PH-302 ...

Background: Ecteinascidin 743 (ET-743) is a marine product that has been suggested to inhibit pregnane xenobiotic receptor (PXR) transcriptional activity based on its ability to down-regulate ...

Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review. Carlos D.F. Fonseca 1 Ondřej Zendulka 1 Jan Juřica 1,2,3 * 1 Department of ... extracts ...

Colchicine should not be used with strong cytochrome P450 3A4 inhibitors or P-glycoprotein in-hibitors, such as clarithromycin, ketoconazole, grapefruit juice, diltiazem and verapamil, she said.