This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

Trilaciclib significantly reduced chemotherapy-induced myelosuppression in extensive-stage small cell lung cancer, which authors say minimizes the need for supportive care.

Furthermore, cellular senescence, driven by DNA damage and disrupted cell cycle ... a dose-dependent increase in senescence markers, such as the cyclin-dependent kinase inhibitor p21 and the ...