Find more information on the Altmetric Attention Score and how the score is calculated. The COX and LOX pathways may modify polyunsaturated NATs and thus alter the activity of NATs in vivo. We ...

The combination of BC and GP downregulates the 5-LOX inflammatory pathway by inhibiting activation of MG and promotes M1-to-M2 polarization of MG. Neurons are protected by the M2-type polarization ...

Background Anti-inflammatory agents are used widely in treating numerous pain and inflammatory conditions. With a focus on the COX/LOX pathways in cutaneous wound ...

Arachidonic acid (AA) is a crucial polyunsaturated fatty acid in the human body, metabolized through the pathways of COX, LOX, and cytochrome P450 oxidase to generate various metabolites. Recent ...

Initially, the in-vitro cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) inhibitory assays were carried out. Peripheral neuropathic pain was induced in the Sprague Dawley (SD) rats by ...

Mouse experiments indicate a favorable response to COX-2 inhibition ... Drugs like montelukast, which affects the LOX pathway, are suggested to be useful in hospitalized COVID-19 patients by ...

Univariate and multivariate Cox regression analysis was used to find independent ... affects the prognosis of gastric cancer patients, we explored the signal pathways related to LOX through GSEA ...

suggesting the greater role played by the activation of enzymes such as COX and LOX in this process. There are many drugs directed at inhibition of the prostaglandin pathway, such as the ...