IC 50 values provide no indication of the mechanism of enzyme inhibition ... (defining both K i values and rate constants) of COX-1 and COX-2 need to be conducted as a first step prior to ...

A novel PET imaging approach can effectively quantify a key enzyme associated with brain inflammation, according to research published in the March issue of The Journal of Nuclear Medicine. The ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition ... NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous ...