Our immune system is constantly working to protect us from infections and injuries. One of its most powerful tools is ...

Harvard Medical School scientists have identified a key protein in the human immune system that drives inflammatory and ...

The kidney damage from C3 glomerulopathy happens when your body’s complement system goes into overdrive. Here’s how it impacts your kidneys.

Both drug prospects should begin Phase 1 trials this year. Like Syfovre and Izervay, CTX114 works on the complement system, ...

The complement system consists of a cascade of linked proteins that are activated in response to infection or tissue damage.

The human complement system is a complex defense system that helps protect the body from pathogens. Similar to the coagulation system, the complement system consists of a cascade of proteases that ...

The Complement group, headed by Prof. Seppo Meri, has for long had an interest in sorting out how and why the complement system contributes to disease pathogenesis, how the system is controlled and ...

A component of the complement system promotes tumor growth by activating myeloid-derived suppressor cells. Figure 1: Multiple pro-inflammatory mediators in the tumor microenvironment increase the ...

Now, over 100 years after the complement system was first described, researchers at Mass General Brigham have discovered that a protein known as granzyme K (GZMK) drives tissue damage and ...

Earlier this year, Apellis Pharma became the first company to claim FDA approval for a drug to treat the condition, Syfovre (pegcetacoplan), which also targets the complement system. Syfovre needs ...

which inhibitor will be the next to harness the complement system for the development of groundbreaking therapies? With assets in nephrology, ophthalmology, neurodegeneration, and inflammation all ...