"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...

That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors, which block prostaglandins that produce inflammation. However, prostaglandins also protect your stomach lining (per the National ...

A drug developer's dream, rationally designed to quell inflammation, COX-2 inhibitors are also prime candidates for ... acute pain, and dysmenorrhea.1 But the use for cancer--begun with the 1999 ...

For example, nimesulide is a weak competitive inhibitor of COX-1 but a potent time-dependent inhibitor of COX-2, whereas celecoxib exhibits slow competitive binding and, at higher concentrations ...