Percent-predicted FEV1 measured before pregnancy did not fall 1 year after in women with highly effective cystic fibrosis ...

The researchers looked at medical records of women who were either on or off modulators who became pregnant in the last 10 ...

in addition to maintenance of wild-type Sprague Dawley strain for additional use Generation and procurement of novel relevant CF animal models to understand newly developed CFTR modulators, and to ...

Gene therapy for cystic fibrosis is advancing fast. Explore key biotech players, clinical progress, and its potential to ...

Join Peter Grootenhuis of Vertex Pharmaceuticals as he delivers a brief overview of the drug discovery approaches and challenges to identify small molecules CFTR modulators. These compounds improve ...

Alyftrek is a type of medicine called a CFTR modulator. Alyftrek is designed to help make the broken CFTR protein in people with cystic fibrosis work better. Since different genetic mutations can ...

Vertex's products are known as cystic fibrosis transmembrane conductance regulator modulators, or CFTR modulators, and they "fix" the malfunctioning protein made by the CFTR gene. Now the tricky ...

and the evaluation and rapidly evolving role of CFTR modulators in human subjects, including a variety of effects on the endocrine and digestive system. The Clinical and Translational Core, ...

Other treatments may include antibiotics, pancreatic enzymes, a high-calorie diet, and newer generation drugs known as CFTR modulators. Severe cases may require a lung transplant. There is no cure ...

People with cystic fibrosis have better treatment options available today than ever before, with the advent of ‘CFTR modulator’ drugs. However, there are still many patients who are unable to ...

Although recent advancements in CFTR modulator therapies have improved outcomes for many people with CF, those with certain mutations remain underserved because these mutations prevent the ...

Sionna is also developing a portfolio of complementary CFTR modulators that are designed to work synergistically with its NBD1 stabilizers to improve CFTR function. For more information about ...