Proliferation is probably an early event, followed by a chronic process that provides an essential fibrous cap that prevents plaque rupture. With the recognition of the essential involvement of ...

These lesions, called atherosclerotic plaques, result in the hardening and obstruction of the arteries; moreover, rupture of an atherosclerotic plaque can cause the formation of thrombi that can ...

The final stage of atheroma progression is characterized by a large necrotic core and low SMC density, with a correspondingly thin fibrous cap — a vulnerable plaque prone to rupture and thrombosis.

Coronary plaque rupture is known to be a major cause of sudden coronary death, but it is also commonly seen in non-coronary sudden death, and can be a clinically silent cause of plaque progression.

"The emergence of DT-109 as a dual-action drug capable of treating both MASH and the vascular complications associated with atherosclerosis marks a significant advancement in the treatment ...

and eventual complications like plaque rupture and heart attacks. So when we had the chance to apply this cutting-edge technology to such an old and challenging problem, we jumped at it”. They ...