but there is increasing evidence of intracrine signaling via nuclear receptors. Here, we examined the nuclear localisation of AT1 (AT1R) and AT2 (AT2R) receptors and their potential functional role.

ABSTRACT: The loss of balance between the antagonistic activities of angiotensin II AT1/AT2 receptors has been impli-cated as a major mediator in the development of hypertension and progressive ...

led a team that, by poking individual cells with a tiny pipette, hit upon a receptor that responds to pressure, touch and the positioning of body parts. After Dr. Julius’s pivotal discovery of a ...

Addition of PDGFA induced AT1 and AT2 differentiation in both mouse and human IPF lung ... Increased platelet-derived growth factor subunit A (PDGFA)/platelet-derived growth factor receptor A ...

Likewise, the anti-fibrotic effects of a drug that acted through the AT2 receptor were indirectly abrogated by compounds that blocked the activity of RXFP1 or the AT1 receptor in myofibroblasts.

In addition, activation of prorenin-renin receptors may contribute to activation of the proinflammatory phenotype. Aged brains showed upregulation of AT1 and downregulation of AT2 receptor expression, ...

“These molecules were derived from AT1 receptor blockers; therefore it was unexpected to find that they transform the AT2 receptor in an active-like state,” Dr. Cherezov said. The researchers ...

"These molecules were derived from AT1 receptor blockers; therefore it was unexpected to find that they transform the AT2 receptor in an active-like state," Cherezov said. The researchers also saw ...

"Unlike its sibling AT1, the AT2 receptor has not been fully understood," said Vadim Cherezov, chemistry professor at the University of Southern California and principal investigator of the study ...

These peptides bind and activate three different subtypes of GPCRs, namely AT1, AT2, and Mas receptors, to regulate cardiovascular functions. Over the past decade, the contribution of several RAS ...