Researchers have created over 400 distinct types of human nerve cells in vitro, vastly expanding the diversity available for ...

Nicotinic acetylcholine (ACh) receptors and other Cys-loop receptors challenge our ability to understand how proteins carry out simple sets of functions — in this case, specific binding ...

The nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels, the activity of which modulates many neurotransmitter systems. They are therefore therapeutic targets for the ...

To identify suitable lipophilic compounds having high potency and selectivity for vesicular acetylcholine transporter (VAChT), a heteroaromatic ring or a phenyl group was introduced into the ...