The paper is published in the journal Cell Reports. The researchers found that ATP-citrate lyase (ACLY), an enzyme involved in converting citrate to acetyl-CoA, plays a critical role in activating ...

Nexletol (bempedoic acid) was approved as an alternative to statins in 2020 as the first drug in the ATP Citrate Lyase (ACL) inhibitor class, and was once tipped as a future blockbuster ...

Esperion continues to build on its success with its next generation program which is focused on developing ATP citrate lyase inhibitors (ACLYi). New insights into the structure and function of ACLYi ...