This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

53BP1 is a key player in DNA repair and together with BRCA1 regulate selection of DNA double strand break repair mechanisms. Localization of DNA repair factors to sites of DNA damage by 53BP1 is ...

PI: YouWei Zhang, Ph.D. Fangfang Wang, a postdoctoral scholar in Dr. You-Wei Zhang's lab, has been awarded a postdoctoral fellowship from the American Cancer Society for her research project titled ...

Alternatively, he said his research is now exploring other avenues to boost the recruitment of the binding protein 53BP1 to replace the function of alpha-synuclein as a possible treatment for ...

Alternatively, he said his research is now exploring other avenues to boost the recruitment of the binding protein 53BP1 to replace the function of alpha-synuclein as a possible treatment for ...

Chemistry/Molecular Biology and Biochemistry $900,000 to study Mechanisms of DNA double-strand break repair by 53BP1-RIF1-shieldin Principal Investigator: Dheva Setiaputra, Molecular Biology and ...

One of those genes, TRID1, summons a protein (called 53BP1) at sites of damage to help repair double-strand breaks in DNA. The species of water bears also calls on other genes to help its ...

53BP1 is a chromatin‐binding protein that promotes DNA double‐strand break repair through the recruitment of downstream effectors including RIF1, shieldin, and CST. The structural basis of the protein ...

Study: SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence. Image Credit: Rost9/Shutterstock Several cellular mechanisms ...

The discovery, involving the protein 53BP1, offers insight into understanding how cells maintain the integrity of DNA in the nucleus, which is critical for preventing diseases like premature aging and ...