Traws Pharma, Inc. (NASDAQ: TRAW) (“Traws Pharma”, “Traws” or “the Company”), a clinical-stage biopharmaceutical company developing novel therapies to target critical threats to human health from ...

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Conclusion There is systemic upregulation of α-defensin and neutrophil protease expression in NA, which may represent proinflammatory effects on the bone marrow and the release of immature neutrophils ...

Proteases that are resident in, or released from, the endolysosomal system of leukocytes have important functions in the immune response. Lysosome-related organelles (LROs) or granules are the ...

Edited by Timothy L. Karr, Arizona State University, Tempe, AZ, and accepted by the Editorial Board December 22, 2011 (received for review June 19, 2011) ...

umn.edu Background: Protease-activated receptor-2 (PAR-2) is present in the pancreas, where it has been shown to play a protective role during pancreatitis. However, the mechanism by which it protects ...

We thank Phillip Ipock for experimental support, Dr. Daria Kim for helpful discussions, and Dr. D. Branch Moody for reading and commenting on the manuscript. We also thank Dr. Thomas Dieffenbach of ...

The group focused on the major protease (MPro), a type of enzyme, or protease, that breaks proteins into smaller pieces like a pair of molecular scissors. SARS-CoV-2 uses MPro to trim viral proteins ...

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China ...

Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, ...

In addition to vaccines, antiviral drugs are now available to target the proteases involved in the replication of SARS-CoV-2. Among the chymotrypsins encoded by the viral genome, understanding the ...