This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

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Two studies reveal promising treatments for breast cancer, enhancing options for patients with triple-negative breast cancer ...

Transcription is an elaborate process that is required to establish and maintain the identity of the more than two hundred cell types of a metazoan organism. Strict regulation of gene expression is ...

Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes ...

Regeneron (REGN) announced initial results from two cohorts of the Phase 1b LINKER-MM2 trial evaluating linvoseltamab in combination with two different proteasome inhibitors – carfilzomib or ...

ABOUT CARVYKTI® (CILTACABTAGENE AUTOLEUCEL; CILTA-CEL) ...

Prof Martin Dreyling discusses the shifting treatment landscape for patients with difficult-to-treat mantle cell lymphoma.

Apple’s iOS 19 is poised to redefine the mobile experience, offering a blend of innovative features and practical improvements. With a focus on artificial intelligence, accessibility ...

UPDATE 2:36 p.m.: Interstate 19 has reopened, according to ADOT. UPDATE 12:15 P.M. According to Drexel Heights Fire District (DHFD), five vehicles were involved in the crash, and one caught fire.

Among these are the chaperones, which include the heat shock proteins (HSP), the ubiquitin proteasome system (UPS), the autophagy–lysosome pathway, and the endoplasmic reticulum (ER)–associated ...

The majority of polyubiquitylated proteins are targeted for degradation by the 26S proteasome, which consists of one or two 19S regulatory complexes attached to the core 20S proteasome. The 19S ...