We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium(III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

Rapid pathogen detection is crucial for effective disease management, particularly in bloodstream infections. Current molecular diagnostics often require nucleic acid preamplification, adding time and ...

Land use change is crucial to addressing the existential threats of climate change and biodiversity loss while enhancing food security [M. Zurek et al., Science 376, 1416–1421 (2022)].The ...

Soft robotics hold immense potential in biomimetics and healthcare due to their exceptional flexibility, adaptability, and biocompatibility (1–3).The development of biomimetic soft robots often relies ...

We thank the Heflin Genomics Institute at UAB, UAB fish facility staff, the University of Massachusetts Chan Medical School (UMass Chan) fish facility, the Research Computing teams at the University ...

Room-temperature superconductors could revolutionize modern technology by enabling lossless power transmission, powerful magnets, advanced medical imaging (MRI), and quantum computing.

Arguably, among the most demanding settings for spatial control of the endolysosomal system are highly polarized cells such as neurons, which consist of complex dendritic arbors and axons that extend ...

Anti-Aβ therapeutics provide only temporary symptom relief in AD while introducing proinflammatory side effects. We describe an “Aβ-STING” immune feedback loop that contributes to AD pathology and, ...

The interior of living cells is compartmentalized into both membrane-bound and membrane-less organelles. Many membrane-less organelles, from nucleoli and Cajal bodies in the nucleus to P-bodies and ...

The UK Biobank has integrated extensive phenotypic and genetic data on over half a million participants, and ongoing initiatives have expanded these resources to include NMR-based metabolic profiling ...

Cotyledon greening is a crucial process for seedlings to survive the dark-to-light transition during their soil emergence. While the complex strategies employed by etiolated seedlings to ensure ...

Lunar meteorites provide a broad sampling of the Moon’s surface that can help us better understand volatile depletion processes acting on our nearest neighbor. Our findings reveal that the Zn and K ...