It was the first all-female spaceflight since June 16, 1963, when the Soviet Union's Valentina Tereshkova launched on a three-day mission to Earth orbit. Tereshkova flew by herself, however, so NS-31 was the first-ever multiperson human spaceflight not to feature a male crewmember.

The Monday morning launch of Blue Origin's New Shepard rocket, was the first all-women spaceflight in more than 60 years.