The molecules that form the foundation of life on Earth are as diverse as they are complex. Among these, carbohydrates play a ...

The serine proteinase plasmin is the key fibrinolytic enzyme that dissolves blood clots and also promotes cell migration and tissue remodeling. Here, we report the 2.65 Å crystal structure of a ...

Considering the geometry of such an enzyme-substrate-complex, they identified three golden rules that should be considered to build a functional enzyme. First, ...

CATALASE is a hsematin enzyme found in relatively large concentrations in erythrocytes, liver, kidney, etc. Its extremely efficient catalysis of the destruction of hydrogen peroxide and its ...

More information: Michalis Chatzittofi et al, Mechanistic rules for de novo design of enzymes, Chem Catalysis (2025). DOI: 10.1016/j.checat.2025.101394 Provided by Max Planck Society ...

The solution to this challenge was provided by Alltech, courtesy of its ‘Digest P3’ enzyme complex. The company’s Adam Smyth was a recent visitor to the Lockharts’ AD operation.

The cysteine protease from the tobacco etch virus (TEVp) is a well-known and widely utilized enzyme. TEVp’s chymotrypsin-like fold is generally associated with serine catalytic triads that differ in ...

The catalytic versatility of pentacoordinated iron is highlighted by the broad range of natural and engineered activities of heme enzymes such as cytochrome P450s, which position a porphyrin cofactor ...

Active-Site-Directed and Enzyme-Activated Irreversible Inhibitors: "Affinity Labels" and "Suicide Inhibitors" Conformational Change, Allosteric Regulation, Motors, and Work; Forces Between Molecules, ...

We propose that MAD2 NT is inserting the 5-LSR-7 segment midway into the narrow pore at the center of TRIP13 in the MAD2–p31-substrate–TRIP13 complex (Fig. 7E), while the 4-LTR-6 segment is captured ...