Kidney transplantation is the treatment of choice for patients with end-stage renal disease, in part because of ongoing efforts towards improving immunosuppressive strategies. Although calcineurin ...

Corticosteroids are used in pharmacologic doses for their anti-inflammatory and immunosuppressive properties. When corticosteroids are used for these purposes, the systemic agents with the least ...

The immunosuppressive medicine regimen you choose will significantly impact your health and overall well-being. I invite you to join me as I guide you through your options and help you select the most ...

Bristol-Myers Squibb’s hopes of adding a new indication to the label for S1P modulator Zeposia have been dented after the drug failed a phase 3 trial in Crohn’s disease. A preliminary analysis ...

The FDA filing comes after a European submission for Zeposia in UC, and is backed up by the results of the True North trial, which showed the drug was able to achieve clinical remission in 18.4% ...

Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is the mechanism that defines how immunosuppressive IDO inhibits immune cell effector functions and/or ...

There are several types of medications that can be used to treat MS, including chemotherapy drugs, anti-inflammatories, immunosuppressive drugs, and steroids. In some cases, medications for MS are ...

In this report, we show, using the DEN/CCl 4 model, that liver injury and fibrosis coincides with the phenotypic exhaustion of CD8 and CD4 T cells as well as a corresponding increase in expression of ...

Severe (proliferative) forms of LN are treated with induction immunosuppressive therapy (IST), followed by maintenance IST, to target remission and avoid relapses. The optimal duration of maintenance ...