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Protein split reveals dual roles in childhood ciliopathies and cell signaling
New research by Sumeda Nandadasa, Ph.D., reveals how a key protein associated with Meckel-Gruber syndrome, nephronophthisis, ...
C&EN15d
Design and Synthesis of PARP/CDK6 Dual-Target Inhibitors Modulating of Wnt/β-Catenin Signaling Pathway for the Treatment of BRCA Wild-Type TNBC | Journal of ... - ACS Publications
Further investigations revealed that 11 could inhibit tumor cell proliferation by modulating the Wnt/β-catenin signaling pathway. In summary, these findings highlight the potential therapeutic ...
ascopubs.org28d
A phase 1/2 study of FOG-001, a first-in-class direct β-catenin: TCF inhibitor, in patients with colorectal cancer (CRC) and other locally advanced or metastatic solid tumors ...
Background: Activation of the Wnt/β-catenin pathway, often as truncal APC mutations, in 80–90% of CRCs and other solid tumors, is known to be a key driver of cancer progression and has been associated ...