John Mascarenhas, MD, discusses the rationale, mechanism, and design of the phase 1 INCA33989-101 and -102 trials investigating a CAL-R–targeted antibody for patients with essential thrombocythemia.

Researchers from The University of Osaka find that a protein expressed on malaria-infected red blood cells both hides it from ...

Moreover, the considerable differences between mouse and human immunoglobulin and Fc receptor subclasses and their expression patterns, as well as the binding of ligands other than immunoglobulins (eg ...

The chemokine receptor CXCR7 is an atypical CXCL12 receptor that, as opposed to the classical CXCL12 receptor CXCR4, signals preferentially via the β-arrestin pathway and does not mediate chemotaxis.

Natural killer (NK) cells play an important role in the innate immune response against tumors and various pathogens such as viruses and bacteria. Their function is controlled by a wide array of ...

From them, 18 (21.7%) isolates grew only in this medium and they showed susceptibility to vancomycin. The medium II, which contained vancomycin 6µg/mL, showed a lower number of positive growing (n=65, ...

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system.In this phase 3, open-label, randomized ...

But all opioid receptors are not the same. In the current study, the researchers targeted KOR, a subtype of opioid receptor that when activated can decrease synaptic dopamine levels by decreasing ...

Objectives To evaluate the safety, tolerability, pharmacokinetics (PK), biomarker response and efficacy of E6742 in a phase I/II study in patients with systemic lupus erythematosus (SLE).Methods Two ...

Discover how bitter taste receptors in the intestines affect aging. A new study identifies specific receptors linked to metabolic changes, inflammation, and lipid metabolism. Learn how these ...