In a study published in Angewandte Chemie International Edition, a research team integrated activity-based protein profiling ...

Mutations or deletions in the gene for POLG yield defective polymerases that cannot stay on the mtDNA template, thus leaving the enzyme’s tasks incomplete. PZL-A binds to an allosteric site on ...

TLR4 endocytosis requires the TLR4 intracellular signaling domain, contributions by phospholipase C gamma 2, spleen tyrosine kinase, E1/E2 ubiquitination enzymes, but not canonical TLR signaling ...

School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China ...

The breakthrough came with a small but powerful idea. They introduced goose lipases – natural enzymes used by birds to break down fat in their digestive systems. These enzymes had never been used in ...

"The TDP-43 aggregates induced by the fibrils exhibited many of the modifications we also see in patient brains, including phosphorylation and ubiquitination. Strikingly, the aggregates were able ...

Digestive enzymes play a crucial role in breaking down food and ensuring the body absorbs essential nutrients efficiently. Without these enzymes, even the healthiest diet may not provide the full ...

Additionally, the development of deubiquitinating enzyme (DUB) inhibitors is an emerging area of ... has shown promise in the treatment of multiple myeloma by promoting the ubiquitination and ...

About 98% of lignin created as a forestry by-product from plants is discarded, but a new enzyme could be the key to extracting high-value molecules from this waste using a green chemistry approach.