Deubiquitinases (DUBs) are enzymes used by cells to trim protein ... targeted treatment could be identified for diseases in which ubiquitination plays a critical role," says Malte Gersch.

TLR4 endocytosis requires the TLR4 intracellular signaling domain, contributions by phospholipase C gamma 2, spleen tyrosine kinase, E1/E2 ubiquitination enzymes, but not canonical TLR signaling ...

The 19S subunit disassembles ubiquitin chains and directs substances into the 20S catalytic core for degradation, while deubiquitinating enzymes (DUBs) recycle ubiquitin for reuse. Ubiquitination ...

School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China ...

Additionally, the development of deubiquitinating enzyme (DUB) inhibitors is an emerging area of ... has shown promise in the treatment of multiple myeloma by promoting the ubiquitination and ...

Digestive enzymes play a crucial role in breaking down food and ensuring the body absorbs essential nutrients efficiently. Without these enzymes, even the healthiest diet may not provide the full ...

Get Instant Summarized Text (Gist) Enzymes have evolved to function at various temperatures, with thermophilic enzymes thriving in heat and psychrophilic enzymes in cold. Ancestral sequence ...

Get Instant Summarized Text (Gist) A new family of enzymes, Ssn endonucleases, has been identified that can specifically target and cut single-stranded DNA. This discovery overcomes a previous ...

Dublin, April 10, 2025 (GLOBE NEWSWIRE) -- The "Industrial Enzymes - A Global Market Overview" report has been added to ResearchAndMarkets.com's offering. The global Industrial Enzymes market is ...