Achieving good oral bioavailability for targeted protein degraders (TPDs) is vital in providing a patient-friendly way to ...

Some two dozen biotech developers of PROTACs, molecular glues and other types of protein-degrading drugs have sprung up over ...

Degradation is a therapeutic strategy that could offer possibilities to get at currently undruggable target proteins. In ...

Zhuhai Yufan Biotechnologies Co. Ltd. has identified molecular glue degraders comprising an E3 ubiquitin protein ligase-binding agent covalently bound to a DNA-binding protein Ikaros (IKZF1)-targeting ...

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...

A research led by the IBB-UAB has managed to decypher the structure of the human protease SENP5, implicated in neurodegenerative disorders, ...

Plants are constantly under siege by pathogens, and their survival depends on precise internal defense strategies. A new ...

Once human proteins are synthesized, they go through some chemical changes. These adjustments control their stability, ...

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their ...

The formation efficiency of the ubiquitin dimer (Ub2) changes significantly depending on the conformational state of the flexible hinge region. Ubiquitination – the addition of the protein ubiquitin - ...