Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, United States Objective: To evaluate the relationship between sperm DNA methylation and DNA damage as determined by the ...

The activities of SOD and GSH-Px, as well as the level of MDA were examined using commercial assay kits. The apoptosis rate of rat hepatocytes in the model groups were detected by TUNEL method.

Fresh mouse tissues were fixed overnight at 4℃ with freshly made 4% PFA (0.4 g paraformaldehyde dissolved in 10 ml PBS, pH 7.4) for immunohistochemical (IHC) /TUNEL assay or with Bouin’s fixative for ...

The FDA acknowledges the necessity of immunogenicity assays to assess immune responses to components of oligonucleotide therapeutics, particularly those with carriers or conjugates.

Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-ARs (α-adrenergic receptors). Plasma membrane cholesterol accumulation affects α 1-AR signaling and ...

State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory & Center for Molecular Imaging and Translational Medicine, National Innovation Platform for Industry-Education ...

This manuscript reports fundamental discoveries on how necrotic cells contribute to organ regeneration through apoptotic signalling to produce cells with non-lethal apoptotic caspase activity that ...