Researchers from the National University of Singapore (NUS) have solved a 60-year-old mystery in bacterial cell envelope ...

Membrane proteins are proteins found in cell membranes, either at the surface or on intracellular organelles. Integral membrane proteins such as receptors and ion channels span the membrane ...

Interferon-induced transmembrane proteins (IFITMs) represent a crucial component of the innate immune response against a broad spectrum of viral pathogens. Central to cellular defence, these ...

A University of California, Riverside-led team has made an advance in the basic understanding of Plasmodium falciparum, the ...

Learn how cell-free protein synthesis helps researchers overcome the challenges of traditional membrane protein production ...

This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct ...

Cornell researchers have found a new and potentially more accurate way to see what proteins are doing inside living cells - using the cells' own components as built-in sensors.

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Essential to cells and their organelles, water is both shuttled to where it is needed and trapped within cellular compartments and structures. Moreover, ordered waters within protein structures often ...

An NMR method for determining the three-dimensional structures of membrane proteins in proteoliposomes is demonstrated by determining the structure of MerFt, the 60-residue helix–loop–helix integral ...

BACKGROUND: Clinical factors discriminate incident atrial fibrillation (AF) risk with moderate accuracy, with only modest improvement after incorporation of polygenic risk scores. Whether emerging ...

When in contact with biological matrices, gold nanoparticles (AuNPs) become coated with a protein corona, which governs their biological identity and mediates interactions with cells and tissues. This ...