DNA topoisomerase enzymes facilitate DNA helix ... other proteins (not shown) are needed for DNA replication. These include a set of initiator proteins to begin each new replication fork at ...

This fundamental role in cell life makes topoisomerase I an important target for cancer therapies: its inhibition leads to ...

Bacterial topoisomerase inhibitors are a promising class of antibiotics that target essential enzymes involved in bacterial DNA replication. These inhibitors work by interfering with the function ...

Researchers at The University of Hong Kong (HKU) have made an exciting discovery about how human cells protect DNA during ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

More information: John Fielden et al, TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts, Nature Communications (2020). DOI: 10.1038/s41467-020-15000-w Provided ...

I continued to focus on problems in virus gene expression and replication when I first ... Our studies of DNA modification enzymes have revealed the mechanism and evolutionary history of topoisomerase ...

and topoisomerase IV (both Type II topoisomerases), which are required for bacterial DNA replication, transcription, repair, and recombination. <18yrs: usually not recommended. See full labeling.

Meiosis reduces ploidy by following one round of DNA replication with two rounds of chromosome segregation ... regulation of TOP-2 in male and female meiosis. Type II DNA topoisomerases (Topo II) are ...

Levofloxacin 5mg/mL; soln for slow IV infusion; preservative-free. Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for ...