Bacterial topoisomerase inhibitors are a promising class of antibiotics that target essential enzymes involved in bacterial DNA replication. These inhibitors work by interfering with the function ...

which is essential for DNA replication and transcription in bacteria. Topoisomerase IV: An enzyme that helps separate intertwined DNA strands during replication, playing a critical role in ...

Gepotidacin is a new triazaacenaphthylene antibiotic that selectively inhibits bacterial DNA replication by interacting ... and the parC subunit of bacterial topoisomerase IV.

Strengths: Top2 is an essential type II topoisomerase that resolves DNA topological stress generated during transcription, replication, chromosome segregation, and other DNA metabolic processes by ...

Gepotidacin inhibits bacterial DNA replication by a novel mechanism of action and binding site, blocking two different type II topoisomerase enzymes, and has shown activity in the lab against ...

topoisomerase will take hold of both of these pieces of ... This process is essential for the processes of cell division and for DNA replication. Quinolones and Fluoroquinolones inter-collate with the ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

A team has unearthed new findings about what happens during the minutes and hours after a cell divides, expanding our understanding of human biology -- and potentially leading to better medicines.

Researchers at The University of Hong Kong (HKU) have made an exciting discovery about how human cells protect DNA during ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted ...

DNA-nanoparticle motors are exactly as they sound: tiny artificial motors that use the structures of DNA and RNA to propel ...

How can DNA from a cheek swab determine if someone is closely related to you? When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works. DNA tests can ...