Researchers have uncovered a surprising mechanism by which a single genetic mutation in the BCL11B gene causes both immune dysfunction and brain development issues.

RIKEN researchers have discovered how a single mutation in one gene can simultaneously result in two symptoms—a severely ...

The thymus gland is part of our lymphatic system. It’s involved in the development of a type of white blood cell called a T lymphocyte. These white blood cells are part of your immune system. They ...

Taniuchi and his team are interested in genetic factors and pathways that underlie the development of the immune system. One such gene, BCL11B, encodes a protein that plays a critical role in the ...

Primary Immunodeficiency (PID) in India poses a significant health concern, with under-recognition hindering diagnosis and treatment accessibility.

"Studying the development of the immune system is ... They found that early in life, most innate-like T cells in the human thymus aren't able to use all of their immune abilities.

[36] Gender-specific patterns in the development of autoimmune diseases ... the combined effects of the reduction in naive T cells (produced by thymus involution) in concert with an activation ...

Financial Highlights for the Year Ended December 31, 2024 Research and development ... and artificial thymus organoids to persist and function post-transplantation, with vascularization and the ...

Specifically, Tet1/3 were essential during development to license the chromatin landscape ... of Tet1/3 in the early and long-term epigenetic programming of CD8 T cells in the thymus. Most notably, ...