Stratton, M. S. & Alberts, D. S. Current application of selective COX-2 inhibitors in cancer prevention and treatment. Oncology (Williston Park) 16 , 37–51 (2002). Google Scholar ...

Functional COX-1 and COX-2 proteins contain 576 and 587 amino acids, respectively, and within the same species COX-1 and COX-2 share 60–65% amino acid sequence identity.

Another therapeutic issue that needs to be clarified is whether COX-2 inhibitors (selective or preferential) should be considered the NSAID treatment of choice in patients who are at risk of ...

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene—a gene that can cause cancer—that may ...

Controlling weight and cardiovascular risk factors is paramount in type 2 diabetes management; however, the definition and ...

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Compound 17k is a potent and selective ATP-competitive inhibitor of Aurora B and C with K i * values of 0.38 ± 0.29 and 1.5 ± 0.4 nM, respectively, and is >250-fold selective over Aurora A.