Every cell in your body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These ...

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more ...

These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

When asteroids like Bennu hit the young Earth, they could have provided a complete package of complex molecules and the ...

Taken together, epigenetic changes that alter chromatin structure have surpassed the proof of principle stage and now offer new dimensions for cancer diagnosis and therapy. With expanding use of ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

The targeting of telomeres offers promise for new cancer therapies, which can be aimed at disrupting the mechanisms that ...

These consortia vary in their scope, funding, and structure from government-funded models such as the National Cancer Institute Experimental Therapeutics Clinical Trials Networks through charitably ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

However, it also protects cells against the loss of another key gene encoding p53 -- a critical tumour suppressor often dubbed the 'guardian of the genome'. Loss of p53 strongly drives the ...