For many eukaryotic introns, splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and associated proteins ...

RALY was identified in the spliceosome complex and in the Drosha microprocessor complex. The m 6 A modification is found to alter RNA structure to enhance HNRNPC binding, and HNRNPA2B1 could bind to ...

Scientists have captured the first detailed 'molecular movie' showing DNA being unzipped at the atomic level -- revealing how cells begin the crucial process of copying their genetic material ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Mar. 19, 2025 — The cells that make up the walls of the finest of all lymphatic vessels have a lobate, oak leaf-like shape that makes them particularly resilient to changes in fluid volume. A ...

2000 - 2003 Post-doctoral Researcher Ludwig Institute of Cancer Research, St Mary´s Hospital, London. 2003 - 2007 Post-doctoral Researcher YCR Institute for Cancer Studies, University of Sheffield.

We characterized back-splicing cis- and trans-elements, and found viral circRNAs resistant to spliceosome perturbation and lacking canonical splice donor-acceptors. Subsequent loss-of-function studies ...

As a consequence, iron-dependent organisms like mammals have evolved complex mechanisms to conserve and recycle iron, preventing its loss and enabling its enhanced absorption during a deficit or in ...