Research carried out on mice has revealed how a hormone released by the intestine acts on the brain and helps regulate the ...

In the present study, a model for the human gonadotropin-releasing hormone receptor embedded in an explicit lipid bilayer was developed. The final conformation was obtained by extensive molecular ...

Somatostatin is a 14-residue peptide hormone originally named for its ability to inhibit the secretion of growth hormone by pituitary somatotropes; however, some 30 years after its discovery, it ...

The human oxytocin receptor is known to exhibit promiscuous activity by coupling to both Gαq and Gαi G proteins to activate distinct signaling pathways. A single-amino acid substitution within the ...

The growth hormone deficiency market is expected to see expansion across the 7MM driven by the introduction of innovative ...

Jun. 8—What parents should know about pediatric growth hormone deficiency (Family Features) Pediatric growth hormone deficiency (GHD) is a relatively rare condition, affecting an estimated 1 in ...

Vepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer: Results of the global, ...

ORCHARD (ClinicalTrials.gov identifier: NCT03944772) is a phase II, biomarker-directed platform study designed to characterize resistance mechanisms and evaluate novel drug combinations in patients ...

Somapacitan (Sogroya, Novo Nordisk) is indicated 'for the replacement of endogenous growth hormone (GH) in children aged 3 years and above, and adolescents with growth failure due to growth hormone ...

Growth failure caused by growth hormone deficiency in people 3 to 17 years is usually treated with somatrogon or somatropin (available in multiple preparations). Somapacitan works in a similar way to ...

Virginia Kaklamani, MD, DSc; and Megan Kruse, MD, discuss how advances in hormone receptor-positive metastatic breast cancer treatment, including ESR1 mutation testing and elacestrant therapy, help ...

Regardless of grade, meningiomas may become refractory, requiring aggressive treatment. When repeated surgery and high-dose radiation are not sufficient to control tumor growth, somatostatin ...